Raphael Chaleil

Dr Raphaël Chaleil

Senior Scientific Officer

Biomolecular Modelling Laboratory,
Cancer Research UK London Research Institute,
Lincoln's Inn Fields, London WC2A 3PX, UK
Bio Molecular Modelling Cancer Research UK

System administration

My role in the lab is to be the system administrator. I administrate the lab's members Linux workstations. I am also in charge of supervising our Linux cluster (166 nodes), used for heavy computation. The Linux cluster is used for running the 3D-JIGSAW server, and for diverse simulations used in the course of the laboratory's research. In addition, I am providing some support and advise to graduate students and post-docs in bioinformatics, programming techniques and biology.

Research

In addition to the system administration, I am involved in various research projects in the lab. My main interests are in Protein Structure Prediction and Protein Docking. On the protein structure prediction side, I am currently working on an entirely new algorithm for the 3D-JIGSAW server. On the protein docking side I am specially interested in protein surface curvature and the role of aromatic residues in protein interactions.

Qualifications

Publications

Alves R., Chaleil R.A.G and Sternberg M.J.E.
Evolution of Enzymes in metabolism: a network perspective
Journal of Molecular Biology, 320(4):751-770, Jul. 2002

Bang J.W., Chaleil R.A.G and Williamson J.
Two stage Bayesian networks for metabolic network prediction
Proceedings of the workshop on quanlitative and model based reasoning in biomedecine
9th Conference on Artificial Intelligence in Medicine Europe, Cyprus, Oct. 2003.

Tamaddoni-Nezhad A., Chaleil R.A.G., Kakas A.C. and Muggleton S.H.
Abduction and induction for learning models of inhibition in metabolic networks.
Machine Learning and Applications, 2005.
Proceedings. Fourth International Conference on
Volume , Issue , 15-17 Dec. 2005 Page(s): 6 pp. -
Digital Object Identifier 10.1109/ICMLA.2005.6

Tamaddoni-Nezhad A., Chaleil R.A.G., Kakas A.C. and Muggleton S.H.
Application of abductive ILP to learning metabolic network inhibition from temporal data.
Machine Learning, 64:209-230, 2006. DOI: 10.1007/s10994-006-8988-x.

Tamaddoni-Nezhad A., Chaleil R.A.G., Kakas A.C., Sternberg M.J.E., Nicholson J. and Muggleton S.
Modelling the effects of toxins in metabolic networks.
IEEE Eng. Med. Biol. Mag., 26(2):37-46. Mar-Apr 2007

Krol M., Chaleil R.A.G., Tournier A.L. and Bates P.A.
Implicit flexibility in protein docking: Cross-docking and local refinement.
Proteins, Aug 2007

Fun Stuff

My hobby is called geocaching, the game is to find hidden boxes with a log book using Global Positioning System.
Here is my stats bar:
Blastwizard

Geocaching stats